Application of Titanium in Pharmaceutical Industry
The pharmaceutical industry is an important industry related to people's physical and mental health, including pharmaceuticals, medical machinery, sanitary materials and other fields, and occupies an important position in the national economy. Titanium is widely used in the pharmaceutical industry because it is non-toxic and harmless, and has good compatibility with the human body.
In pharmaceutical production, because the production of medicines is inseparable from acids, alkalis and salts, pharmaceutical equipment is easily damaged by corrosion. The use of steel equipment not only cannot solve the problem of serious equipment corrosion, but also causes a lot of loss of human, material and financial resources, affecting normal production. The use of titanium equipment solves this problem very well.
In the production of several main commonly used drugs, the equipment made of titanium has good corrosion resistance and obtains considerable economic benefits.
1. Production of vitamin B1
In my country, the hydrogen chloride conversion method is often used to produce vitamin B1, and the finished product is dried by cyclone and separated by two cyclones. The medium is thiamine hydrochloride, the pH value is 2.5, and the temperature is 110 °C, which is highly corrosive. The original drying device was made of stainless steel, and the inner wall was corroded and perforated after more than a year of use, and seriously polluted the medicine.
After adopting titanium screw feeder, cyclone separator, vortex body, hopper and discharge pipe and titanium lining of exhaust box, the production qualification rate of vitamin B1 is increased from the highest 95% to 100%, and the equipment has not been corroded for more than 7 years , the cost of titanium can be recovered in 3 months.
2. Vitamin C production
Vitamin C is sorbitol as raw material, fermented into sorbose with black vinegar bacteria, and then fermented with Pseudomonas to obtain low-concentration gulonic acid, which is converted into finished product by hydrogen chloride after concentration.
Titanium is very resistant to corrosion in high temperature coronic acid. In the production process of this product, titanium tubular heat exchangers, titanium DHC-500 disc sinking type automatic slag discharge centrifuges, and TC4 cast impellers have been used, and no corrosion has been found for many years.
3. Antibiotic production
The main raw material for chemical synthesis of chloramphenicol (an antibiotic) is methyl dichloroacetate, which contains about 2% chlorinated alkene and trichloroethylene. If steel equipment is used in the refining process, it is prone to severe corrosion, and titanium is used instead. The equipment has been intact since its manufacture.
4. Production of anesthetics
Procaine hydrochloride used in local anesthesia is produced with p-nitrotoluene as raw material, and there is strong corrosiveness in the entire production process of oxidation to p-nitrobenzoic acid, acetic acid washing, and mother liquor recovery, so the production equipment The titanium steel composite plate inner cylinder, titanium bubble tube, glacial acetic acid circulating condenser and vapor-liquid separator are used to solve the corrosion problem.
5. Production of anthelmintics and other medicines
Ascaris net (tetraimidazole) is a high-efficiency intestinal nematode anthelmintic. In the production of this product, stainless steel equipment was used, and the product was polluted due to corrosion. After changing to titanium as the feed pipe and pump water pipe, the corrosion problem was successfully solved. .
Nitrochlorophenol is a special veterinary drug for the treatment of Fasciola hepatica in cattle and sheep. It is produced with sulfuric acid, nitric acid, glacial acetic acid and chlorine-containing solution. Titanium dosing tank agitator is used, and it has been running normally so far. In addition, activated carbon is generally used for decolorization in pharmaceutical production. After the stainless steel suction filter is changed to a titanium suction filter, it is still in good condition after 9 years of use.
In the production of brominated amino acids abroad, titanium reactors are used in the processes of bromination, separation, salting out, extraction and steaming. In my country, it is also necessary to use titanium equipment for the preparation of malaria drugs, anti-schistosomiasis drugs, contraceptives, and rheumatism drugs that use quinoline derivatives to contact chloride ions. Others such as penicillin esterification kettle, saccharification tank, chloramphenicol thin film evaporator, analgin reactor, mitol filter, dimethyl sulfate cooler, liquid medicine filter, etc., are all feasible to use titanium materials. nature and necessity.
